can create later problems in the crops, which can increase the cost of their use. Another important aspect of the studies that will follow this work is to observe how cannibalism benefits these predators from a chemical perspective. That is, what substances are modified or appear in the body with respect to non-cannibalistic individuals. The work has had the participation of mathematicians, biologists, entomologists and agronomists and is part of the results obtained through the excellence project of ‘Biological Control of the introduced pest species: Tuta absolu , in tomato crops in Spain’, financed by the Ministry of Economy and Knowledge of the Junta de Andalucí a model organism, and supported by genome editing techniques, researchers Carlos Estella and Sergio Córdoba from the Autonomous University of Madrid (UAM) and the “Severo Ochoa” Molecular Biology Center

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CBMSO) have now figured out how this genetic program works. Their results, published in the journal Development , suggest the existence of a primitive and highly conserved Denmark Email List mechanism by which the genes of the Sp family regulate the growth of appendages in both flies and vertebrates. “Through a transcriptomic analysis we were able to identify those genes responsible for controlling the growth of the fly’s legs, which are regulated by Sp1, which is one of the members of the Sp family in Drosophila . Thus we discovered that the transcription factor Sp1 regulates an essential component of the Notch signaling pathway ”, explains Carlos Estella. The Notch signaling pathway is highly conserved throughout the animal kingdom and is involved in a multitude of developmental processes, including growth control. “What our work suggests is that it is possible that

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nature has invented the basic mechanism to form the appendages only once, and that both arthropods and vertebrates use modifications of this genetic program to make their different types of limbs,” he points out. Sergio Cordoba. Deep homology Although the limbs of humans and those of flies are structures with analogous functions, their morphology and development are completely different: while a person’s legs are made up of different tissues, such as bone, cartilage, muscle and skin, the legs of A fly is simple tubes formed from a chitin exoskeleton that are connected by internal muscles. Yet despite the anatomical differences between a fly and a vertebrate, and their independent evolution over more than 500 million years, the development of both is largely driven by strikingly similar basic genetic programs. This is what in Biology Development is known as ‘deep homology’

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