encodes small proteins from the group of hub proteins (proteins connected to many other proteins) that change their configuration according to the molecular context in the one they meet. The article confirms that the BEX / TCEAL gene group originated through a process known as molecular domestication of transposons (mobile genetic elements that can be inserted in different places in the genome). Through this process, a non-functional transposon gene can become a new active component of the genome (domesticated transposon) that evolves in a similar way to other genes. Transposons are considered a source of evolutionary innovation and adaptation in living beings. “They are genetic components that normally have no function or are

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detrimental to the host genome. However, in the case Belgium WhatsApp Number List of the BEX / TCEAL cluster they were domesticated by the molecular machinery of the ancestor of placental mammals. In other words, they became new genes ”, points out Professor Jordi Garcia Fernàndez, director of the Department of Genetics, Microbiology and Statistics at the UB and head of the Evolution and Development Research Group ( Evo-Devo ). During the evolutionary process, transposons can lose their ability to jump “due to new mutations, which, added to the effects of the neighborhood of the regulatory regions where they are found, transform these mobile components into genuinely new genes that have not appeared previously during the evolutionary process. evolution:

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they are absolute gene novelties ”, explains researcher Enrique Navas Pérez (UB-IBUB), who is the first author of the article. “It is very possible that events like this one that we describe have had great importance in the establishment of unique characteristics of mammals”, points out Jaime Carvajal, deputy director of the Andalusian Center for Developmental Biology and head of the Molecular Embryology Research Group. “We are therefore looking at the function of a series of genes that may have contributed to establishing specific brain properties of placental mammals,” he adds. Cristina Vicente García, also the first author of the article along with Enrique Navas Pérez and Serena Mirra, specifies that “despite being very young genes in

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