“With this work, in addition to solving the problems surrounding the relationship between Decennatherium pachecoi and Birgerbohlinia schaubi, we have clarified the situation of some fossils that were found during the 1980s in the Middle East and Eastern Europe and that, erroneously , they had been assigned to the genus Decennatherium ”, clarifies Ríos. (chordates), has lost most of the genes related to the metabolism of retinoic acid, according to the article published in the journal Molecular Biology and Evolution, one of the indexed scientific publications with the greatest impact in its field of knowledge. Retinoic acid (AR) is a molecule derived from vitamin A (retinol) that is key in physiology and embryonic development in the human species and in the whole of our phylum. The loss of genes would have made it easier for O.

dioica to develop without depending Bermuda Email Lists on vitamin A, which would be a new example of how the phenomenon of gene loss can be an evolutionary strategy that allows the adaptation of species to certain scenarios biological advantageously. The new study has been carried out by researchers Josep Martí Solans, Núria P. Torres Águila, Ricard Albalat and Cristian Cañestro, from the Department of Genetics, Microbiology and Statistics and the Biodiversity Research Institute (IRBio ) of the University of Barcelona, With the collaboration of researchers Olga V. Belyaev and Natalia Y. Kedishvili, from the University of Alabama (United States). When evolution is regressive In many chordates, RA is an essential factor to regulate the expression of genes involved in the processes of cell proliferation and differentiation,

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such as those that occur during the embryonic development of organs and systems, or in the formation of body symmetry patterns. Some genetic diseases also involve alterations in the action of RA that can cause imbalances in cell proliferation and the development of cancers such as acute promyelocytic leukemia. The chordate O. dioica is an organism evolutionarily very close to vertebrates, with which it shares a similar body plan and various organs or homologous structures, such as the heart, brain or skeletal muscles, whose development depends on RA. One of the great challenges of the published work has been to demonstrate that, despite the fact that many of these organs develop normally in O. dioica, this process occurs in the absence of RA due to the massive loss of genes involved in the

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