A team led by scientists from the UPF Department of Experimental and Health Sciences ( DCEXS ) and the Institute of Evolutionary Biology ( IBE ), a joint UPF and CSIC center , have shown what the ultimate genetic causes of aging are human . The results are published this week in the journal Nature Ecology & Evolution . Aging has long been a challenge to the public health system and a fascinating scientific conundrum for evolutionary biologists. There is no universal theory about its causes, and it is not clear what its global impact on human health will be. Now, this study has taken advantage of all the data accumulated during a decade of research on the genetic bases of complex diseases – from Parkinson’s to cancer to diabetes – to test different evolutionary theories of senescence. Until now, efforts to understand the evolutionary causes of aging were

Social Media and Email Marketing

limited to experimental models such as the fruit Guyana Email List fly, and the conclusions were often contradictory. But today, the amount of data available on the relationship between genotype and phenotype represents an unprecedented opportunity to carry out these analyzes in humans. This information is made available to the scientific community from large international databases such as the European Genome Phenome Archive ( EGA ): a joint project between the European Institute of Bioinformatics ( EBI , Cambridge) and the Center for Genomic Regulation ( CRG , Barcelona). ). Arcadi Navarro , former ICREA research professor at UPF, has co-led the study in which the results of some 3,000 studies with more than 2,500 markers on a total of 120 diseases have been examined . According to Navarro , “The power to determine if an individual is healthy or if he will develop a disease

Guyana Email List
throughout life has increased greatly as more and more data has been collected.” To begin with, scientists have considered whether the markers for each disease have an effect on youth or old age . The distinction is very important because if a mutation has harmful consequences in old age, our genes will have already been passed on to our offspring and natural selection will not be able to act. The results of this study show that the frequency and effect of mutations that cause disease in old age are greater than those that cause disease in early age. “We have found an evolutionary threshold at 40-50 years , a biologically significant age because it limits the reproductive period,” says Navarro. Bioinformatics studies carried out by Juan Antonio Rodríguez, first author of the work, have also shown that there are mutations that are beneficial in

Leave a Reply

Your email address will not be published. Required fields are marked *