on its origin. ” However, it is striking that pangolin viruses contain some genomic regions that are closely related to the human virus .” To delve into the subject, it will be necessary to obtain samples of coronavirus from bats from the Hubei region, where the COVID-19 pandemic originated, and new samples from pangolins or other species. What is the evolutionary history of the virus? Although everything indicates that the SARS-CoV-2 virus arose through a transfer from an animal, the exact steps are unknown. Pieces in the evolutionary history of the virus are still missing to complete a detailed picture of what happened at each stage. For example, the genome of coronaviruses obtained from pangolin shows a variation in the binding domain of protein S,

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which is involved in binding and entering host cells. This feature is also present in human-derived SARS-CoV-2 but not in similar coronaviruses isolated from bats. This would support the Senegal Phone Number List virus to first jump from bat to pangolin, acquire that change, and then jump to humans. However, the SARS-CoV-2 genome has another feature absent from the genome of coronaviruses isolated from bats and pangolins: a sequence that favors cleavage of the peptides that make up protein S. It is not yet known whether that change could have occurred in another species before the transfer or occurred after, in the human species. Answering this question could be of interest in determining previous human exposure to SARS-CoV-2. Synthetic origin rejected When a

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pathogen as aggressive as SARS-CoV-2 arises, it does not take long to consider that it is a designer biological weapon released intentionally or by accident. The first analyzes of the SARS-CoV-2 genome suggest that there is no evidence that it was created or manipulated. The structure of the genome is not the one that would correspond to the manipulation of a genome. There is nothing to indicate that it was created from the pattern of another virus. Furthermore, its sequence is not optimized to give rise to proteins with higher affinity for its receptor in the host. “There is simply no evidence that SARS-CoV-2, the cause of COVID19, emerged from a laboratory,” Holmes notes. “This is actually the kind of natural emergency event of a disease that researchers in

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