process can provide insights into understanding aging processes. The work has been published in the journal Current Biology . An important part of the formation of the development and growth of the various parts of the adult body is the dismantling of organs and structures from earlier stages. The most obvious example is metamorphosis in insects, but in people this process also occurs during the development of the sexual glands or in the involution of the breast, in periods of post-lactation. A work co-led by Dr. Jordi Casanova , head of the Drosophila Development and Morphogenesis laboratory at IRB Barcelona, ​​also a

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researcher at the IBMB-CSIC, and Dr. Jérôme Solon, Estonia WhatsApp Number List previously at the Center for Genomic Regulation and now a researcher at Ikerbasque, has described the dismantling of the trachea of ​​the Drosophila fly during metamorphosis. The process takes place in two phases: the first consists of a shortening / shrinking of the trachea, which causes a compaction of the cell membranes, thus initiating the second phase, characterized by cell death. In this second phase, not all the cells of the initial trachea die uniformly, but the so-called progenitor cells are saved, thus giving rise to the adult organ. “In the end, aging is a stage of development, where there are structures that, due to use or wear, are dismantled. If we want to understand aging and work to

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build a healthy old age, it is essential to understand these processes ”, explains Dr. Casanova . Dr. Fraire-Zamora and Dr. Solon noted the need for these interdisciplinary collaborations for future discoveries: “An interesting aspect of this process, which leads to the dismantling of a multicellular organ, is the intricate involvement of physical mechanisms and signaling. biological. Together, they control cellular decisions and organ remodeling. Therefore, this work highlights that, to understand complex processes during animal development or in diseases, we not only need to reveal the genetic expression or biochemical activity of cells, but also reveal their physical state and understand their mechanics ” . The first author of this article is Dr. Juan J. Fraire-

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